{"status":"OK","data":{"advertisement":{"id":348347,"title":"Przeprowadzenie eksperymentalnej weryfikacji min. 1500 moleku\u0142 na potrzeby firmy NaturalAntibody S.A. w projekcie pt. \u201eBioOptimizer - technologia oparta o AI pozwalaj\u0105ca zaprojektowa\u0107 przeciwcia\u0142a o po\u017c\u0105danych cechach terapeutycznych\u201d w Programie  Fundusze Europejskie dla Nowoczesnej Gospodarki Priorytet 5. Wsparcie projekt\u00f3w realizuj\u0105cych cele inicjatywy STEP \u015acie\u017cka A: Projekty realizowane w sektorze biotechnologie (NCBR), nab\u00f3r FENG.05.01-IP.01-001/25 | Conducting experimental validation of at least 1,500 molecules for NaturalAntibody S.A. under the project entitled \u201cBioOptimizer \u2013 an AI-based technology enabling the design of antibodies with desired therapeutic properties\u201d, proposed under the European Funds for a Modern Economy Programme, Priority 5: Support for projects implementing the objectives of the STEP initiative, Path A: Projects in the biotechnology sector (NCBR), call FENG.05.01-IP.01-003/25.","partial_offer_allowed":false,"publication_date":"2026-02-10","submission_deadline":"2026-03-13 01:00:00","planned_sign_date":"2026-05-01","supplementary_orders":null,"terms_of_contract_change":"1.\tZamawiaj\u0105cy przewiduje mo\u017cliwo\u015b\u0107 zmian postanowie\u0144 zawartej umowy w stos. do tre\u015bci oferty, na podst. kt\u00f3rej dokonano wyboru Wykonawcy, w przypadku wyst\u0105pienia min. 1 z okoliczno\u015bci wymienionych poni\u017cej, z uwzg. podawanych warunk\u00f3w ich wprowadzenia, tj.:\n1)\tzmiany dot. realizacji dodatkowych dostaw od dotychczasowego Wykonawcy nieobj\u0119tych zam\u00f3wieniem podst., o ile sta\u0142y si\u0119 niezb\u0119dne i zosta\u0142y spe\u0142nione \u0142\u0105cznie nast. warunki:\na)\tzmiana Wykonawcy nie mo\u017ce zosta\u0107 dokonana z powod\u00f3w ekon. lub techn., w szczeg\u00f3lno\u015bci dot. zamienno\u015bci lub interoperacyjno\u015bci sprz\u0119tu, us\u0142ug lub instalacji, zam\u00f3wionych w ramach zam\u00f3wienia podst.,\nb)\tzmiana Wykonawcy spowodowa\u0142aby istotn\u0105 niedogodno\u015b\u0107 lub znaczne zwi\u0119kszenie koszt\u00f3w dla Zamawiaj\u0105cego,\nc)\twarto\u015b\u0107 ka\u017cdej kolejnej zmiany nie przekracza 50% warto\u015bci zam\u00f3wienia okre\u015blonej pierwotnie w umowie,\n2) zmiana nie prowadzi do zmiany charakteru umowy i zosta\u0142y spe\u0142nione \u0142\u0105cznie nast. warunki:\na)\tkonieczno\u015b\u0107 zmiany umowy spow. jest okoliczno\u015bciami, kt\u00f3rych Zamawiaj\u0105cy, dzia\u0142aj\u0105c z nale\u017cyt\u0105 staranno\u015bci\u0105, nie m\u00f3g\u0142 przewidzie\u0107,\nb)\twarto\u015b\u0107 zmiany nie przekracza 50% wart. zam\u00f3wienia okre\u015bl. pierwotnie w umowie,\n3) Wykonawc\u0119, kt\u00f3remu Zamawiaj\u0105cy udzieli\u0142 zam\u00f3wienia, ma zast\u0105pi\u0107 nowy Wykonawca:\na)\tw wyniku sukcesji, wst\u0119puj\u0105c w prawa i obowi\u0105zki Wykonawcy, w nast. przej\u0119cia, po\u0142\u0105czenia, podzia\u0142u, przekszta\u0142cenia, upad\u0142o\u015bci, restrukturyzacji, dziedziczenia lub nabycia dotychczasowego Wykonawcy lub jego przedsi\u0119biorstwa, o ile nowy Wykonawca spe\u0142nia warunki udzia\u0142u w post\u0119p. i nie poci\u0105ga to za sob\u0105 innych istotnych zmian umowy, a tak\u017ce nie ma na celu unikni\u0119cia stos. zasady konkurenc.,\n4) zmiana nie prowadzi do zmiany charakteru umowy i jest mniejsza od 10% wart. zam\u00f3wienia okre\u015bl. pierw. w umowie,\n5) zmiana sposobu rozliczania umowy, dok. p\u0142atn. lub konieczn. zmiany terminu realiz. na rzecz ka\u017cdej ze Stron, na umotyw. ich wniosek,\n6) wyst\u0105pienia konieczno\u015bci zwi\u0119kszenia / zmniejszenia zakresu przedmiotu zam\u00f3wienia o warto\u015bci 10%\n7) wyst\u0105pienia si\u0142y wy\u017cszej,\n8) zmiana wynika z okoliczn. wyw. wyst\u0105pieniem epidemii COVID 19.\n2.\tPonadto Zamawiaj\u0105cy dopuszcza ist. zmiany post. umowy w nast. przyp. i zakresie:\n1)\tsposobu wyk. przedmiotu umowy wsk. wyst\u0105pienia okoliczn., kt\u00f3rych Zamaw. i Wykon. nie byli w stanie przewidzie\u0107, mimo zachow. nale\u017cytej staranno\u015bci,\n2)\twynagrodzenia w razie zmiany przepis\u00f3w podatkowych, w szczeg. zmiany stawki podatku od towar\u00f3w i us\u0142ug,\n3)\tzmian powsz. obow. przepis\u00f3w prawa w zakr. maj\u0105cym wp\u0142yw na realizacj\u0119 umowy,\n4)\tzmiany zasad p\u0142atn wynagr. Wykonawcy, gdy konieczno\u015b\u0107 wprow. zmian b\u0119dzie nast\u0119pstwem postan. in. um\u00f3w maj. zw. z umow\u0105 dot. nin. post\u0119p., a konieczn. zmian wynika z okoliczn., kt\u00f3rych nie mo\u017cna by\u0142o przew. w chwili zaw. umowy\n5)\tin. zmian na sk. okoliczn., kt\u00f3rych Strony nie mog\u0142y przew. w chwili zaw. umowy,\n6)\tzmiany okresu realiz. przedm. umowy, zmiany zakr. przedm. umowy w ram. ca\u0142ego proj. wynik. z potrzeb Zamaw. w razie zaakcept. przez Instyt. b\u0119d\u0105c\u0105 str. Umowy o dofinans. projektu zmian we Wniosku o dofinans.\n3.\tZmiany umowy wym. dla swej wa\u017cno\u015bci aneksu w formie pis. pod rygorem niewa\u017cn.\n***\n1. The Purchaser reserves the right to amend the concluded agreement in relation to the content of the offer submitted by the selected Tenderer, provided that at least one of the following circumstances occurs and the conditions for their application are met:\n\t1) Amendm. concerning additional supplies from the existing Tenderer not covered by the original contract, where such supplies have become necessary and all of the following conditions are met:\na) a change of Tenderer is not possible for economic or technical reasons, in particular due to interoperability or interchangeability requirements,\nb) a change of Tenderer would cause significant inconvenience or a substantial increase in costs for the Purchaser,\nc) the value of each amendm. does not exceed 50% of the original contract value.\n2) Amendm. which do not alter the nature of the contract, provided that:\na) the need for amendment results from circumstances which the Purchaser, exercising due diligence, could not have foreseen,\nb) the value of the amendment does not exceed 50% of the original contract value.\n3) Replacement of the original Tenderer with a new Tenderer as a result of legal succession (including acquisition, merger, division, transformation, bankruptcy, restructuring, inheritance, or purchase of the enterprise), provided that the new Tenderer meets the participation requirements, the replacement does not introduce other material changes, and does not circumvent competition.\n4) Amendm. which do not alter the nature of the contract and whose value is less than 10% of the original contract value.\n5) Amendm. to settlement methods, payment terms, or performance deadlines, made in favour of either Party upon a justified request.\n6) An increase or decrease in the scope of the contract subject matter by up to 10% of its value.\n7) Occurrence of force majeure.\n8) Amendm. resulting from circumstances related to the COVID-19 epidemic.\n2. The Purchaser also allows material amendments to the agreement in the following cases:\n1) Modification of contract performance due to unforeseeable circumstances beyond the control of either Party despite due diligence.\n2) Adjustment of the Tenderer\u2019s remuneration resulting from changes in tax regulations, in particular VAT rates.\n3) Amendments arising from changes in generally applicable laws affecting contract performance.\n4) Modification of payment rules where required by other agreements related to this contract and resulting from unforeseeable circumstances.\n5) Other amendments resulting from circumstances unforeseeable at the time of contract conclusion.\n6) Amendment of the contract performance period or scope within the project, subject to approval by the Institution party to the Co-financing Agreement, reflecting changes in the Grant Application.\n3. Any amendment to the agreement shall be valid only if made in writing.","created_at":"2026-02-10 23:28:49","modified_at":"2026-03-13 01:00:15","contact_persons":[{"id":102237,"forename":"Agnieszka ","surname":"Ko\u0142odziejak","phone_number":"+48 791 750 358","email":"agnieszka.kolodziejak@naturalantibody.com","created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 23:28:49","modified_by":null}],"orders":[{"id":562765,"estimated_value":"6573420,00","order_items":[{"id":633959,"description":"Przedmiotem zam\u00f3wienia jest przeprowadzenie eksperymentalnej weryfikacji minimum 1500 moleku\u0142, z czego co najmniej 1000 w ramach zadania 1 oraz 500 w ramach zadania 2 na potrzeby firmy NaturalAntibody S.A. w projekcie pt. \u201eBioOptimizer - technologia oparta o AI pozwalaj\u0105ca zaprojektowa\u0107 przeciwcia\u0142a o po\u017c\u0105danych cechach terapeutycznych\u201d w Programie Fundusze Europejskie dla Nowoczesnej Gospodarki Priorytet 5. Wsparcie projekt\u00f3w realizuj\u0105cych cele inicjatywy STEP \u015acie\u017cka A: Technologie cyfrowe i innowacje w ramach g\u0142\u0119bokich technologii, nab\u00f3r FENG 05.01-IP.01-003/25.\nZamawiaj\u0105cy przeka\u017ce Wykonawcy:\n-\tsekwencje przeciwcia\u0142,\n-\todpowiadaj\u0105ce im antygeny,\n-\tkomplet danych w postaci arkusza kalkulacyjnego, niezb\u0119dnych do rozpocz\u0119cia prac.\nZakres odpowiedzialno\u015bci Wykonawcy:\n-\twytworzenie odpowiednich ilo\u015bci przeciwcia\u0142 w klasie IgG.\n-\tzapewnienie minimalnych ilo\u015bci przeciwcia\u0142 i antygen\u00f3w niezb\u0119dnych do realizacji wszystkich zaplanowanych eksperyment\u00f3w.\nWykonawca nie jest zobowi\u0105zany do samodzielnej syntezy antygenu ani konstrukcji gen\u00f3w/plazmid\u00f3w. Mo\u017ce zakupi\u0107 antygeny lub geny/plazmidy od zewn\u0119trznych dostawc\u00f3w, w przypadku ich braku w laboratorium.\nZakres bada\u0144 eksperymentalnych:\n-\tspecyficzno\u015bci wi\u0105zania antygenu,\n-\tpowinowactwa (affinity), \n-\ttermostabilno\u015bci,\n-\tsk\u0142onno\u015bci do agregacji.\nHarmonogram realizacji\n-\tZadanie 1: maksymalnie 12 tygodni od z\u0142o\u017cenia zam\u00f3wienia,\n-\tZadanie 2: maksymalnie 4 tygodnie od z\u0142o\u017cenia zam\u00f3wienia.\nPo zako\u0144czeniu prac Wykonawca sporz\u0105dzi raport ko\u0144cowy, zawieraj\u0105cy:\n-\tzestawienie sekwencji przekazanych przez Zamawiaj\u0105cego,\n-\twyniki bada\u0144 w postaci surowych danych oraz analiz ilo\u015bciowych,\n-\tdane umo\u017cliwiaj\u0105ce dalsze por\u00f3wnania z wynikami in silico.\n\n***\n\nThe subject of the contract is the performance of experimental verification of a minimum of 1,500 molecules for the benefit of NaturalAntibody S.A., within the project entitled \u201cBioOptimizer \u2013 an AI-based technology enabling the design of antibodies with desired therapeutic properties\u201d, implemented under the European Funds for a Modern Economy Programme, Priority 5: Support for projects implementing the objectives of the STEP initiative, Path A: Digital technologies and innovations within deep-tech technologies, call FENG.05.01-IP.01-003/25.\nThe Contracting Authority shall provide the Contractor with:\n-\tantibody sequences,\n-\tthe corresponding antigens,\n-\ta complete dataset in the form of a spreadsheet, necessary to commence the works.\nScope of the Tenderer\u2019s responsibilities:\n-\tproduction of appropriate quantities of antibodies in the IgG class,\n-\tensuring minimum quantities of antibodies and antigens necessary for the performance of all planned experiments.\nThe Tenderer is not required to independently synthesise antigens or construct genes/plasmids. The Tenderer may purchase antigens or genes/plasmids from external suppliers in the event that such materials are not available in the laboratory..\nScope of experimental studies:\n-\tantigen binding specificity,\n-\taffinity,\n-\tthermostability,\n-\taggregation propensity.\nImplementation schedule:\n-\tTask 1: up to 12 weeks from the date of placing the order,\n-\tTask 2: up to 4 weeks from the date of placing the order.\nUpon completion of the works, the Tenderer shall prepare a final report containing:\n-\ta list of sequences provided by the Contracting Authority,\n-\tresearch results in the form of raw data and quantitative analyses,\n-\tdata enabling further comparison with in silico results.\n\n","warranty_period":"12 miesi\u0119cy","cpv_items":[{"id":8515,"code":"73111000-3","name":"Laboratoryjne us\u0142ugi badawcze"}],"timetable_items":[],"fulfillment_places":[{"country":"Polska","voivodeship":null,"poviat":null,"commune":null,"locality":null,"created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 23:28:51","modified_by":null,"id":719670,"type":{"id":2,"name":"ca\u0142a Polska"},"group_uuid":"70298bd8-4a79-4f75-af67-67b8a0ef78d7"}],"participation_conditions":[{"id":1800541,"description":"Wykonawca dysponuje kadr\u0105 posiadaj\u0105c\u0105 wiedz\u0119 i do\u015bwiadczenie w zakresie biologii molekularnej, obejmuj\u0105ce w szczeg\u00f3lno\u015bci:\n-\treakcj\u0119 \u0142a\u0144cuchow\u0105 polimerazy (PCR),\n-\tsekwencjonowanie przeciwcia\u0142,\n-\tprac\u0119 ze z\u0142o\u017conymi protoko\u0142ami laboratoryjnymi oraz odczynnikami chemicznymi,\n-\tsekwencjonowanie nowej generacji (NGS),\n-\tprzygotowanie bibliotek fagowych (phage display),\n-\ttechnologie ELISA oraz wysokosprawn\u0105 chromatografi\u0119 cieczow\u0105 (HPLC-SEC).\nWykonawca dysponuje kadr\u0105 posiadaj\u0105c\u0105 co najmniej 2-letnie do\u015bwiadczenie w zakresie:\n-\tplanowania i realizacji eksperyment\u00f3w,\n-\tanalizy i interpretacji zbior\u00f3w danych eksperymentalnych,\n-\trozwi\u0105zywania problem\u00f3w pojawiaj\u0105cych si\u0119 w trakcie realizacji bada\u0144, przygotowywania raport\u00f3w oraz prezentowania wynik\u00f3w prac badawczych.\n\n***\nThe Tenderer has personnel with knowledge and experience in the field of molecular biology, including in particular:\n-\tpolymerase chain reaction (PCR),\n-\tantibody sequencing,\n-\twork with complex laboratory protocols and chemical reagents,\n-\tnext-generation sequencing (NGS),\n-\tpreparation of phage libraries (phage display),\n-\tELISA technologies and high-performance liquid chromatography (HPLC-SEC).\nThe Tenderer has personnel with at least 2 years of experience in the field of:\n-\tplanning and conducting experiments,\n-\tanalysis and interpretation of experimental datasets,\n-\ttroubleshooting during the conduct of research,\n-\tpreparation of reports and presentation of research results.","type":{"id":2,"name":"Wiedza i do\u015bwiadczenie"},"created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 23:28:49","modified_by":null,"group_uuid":"a31ac6fd-49b2-460f-8b5c-a6060448367a"},{"id":1800542,"description":"Wykonawca musi posiada\u0107 niezb\u0119dne zasoby techniczne konieczne do prawid\u0142owego wykonania przedmiotu zam\u00f3wienia.\nMinimalne zasoby techniczne:\n- inkubator do hodowli kom\u00f3rek/wir\u00f3wka orbitalna,\n- wir\u00f3wka do p\u0142ytek o g\u0142\u0119bokich studzienkach analitycznych,\n- wysokosprawny chromatograf cieczowy HPLC,\n- urz\u0105dzenie do pomiaru oddzia\u0142ywa\u0144 biomolekularnych umo\u017cliwiaj\u0105ce analiz\u0119 kinetyki i powinowactwa bez znakowania w czasie rzeczywistym,\n- urz\u0105dzenie do pomiaru st\u0119\u017cenia bia\u0142ka,\n-  czytnik p\u0142ytek testu immunoenzymatycznego,\n- urz\u0105dzenie do analiz fluorescencji bia\u0142ek w funkcji temperatury (od 35-95\u2218C) do oceny ich jako\u015bci i stabilno\u015bci przy d\u0142ugo\u015bciach fal 330 i 350 nm,\n- p\u00f3\u0142automatyczny system chromatograficzny do oczyszczania przeciwcia\u0142 z mo\u017cliwo\u015bci\u0105 pomiaru st\u0119\u017cenia bia\u0142ka (system Fast Protein Liquid Chromatography (FPLC) lub r\u00f3wnowa\u017cny).\n***\nThe Tenderer must have the necessary technical resources for the proper execution of the subject of the contract.\nMinimum technical resources:\n- incubator for cell culture / orbital centrifuge,\n- centrifuge for deep-well analytical plates,\n- high-performance liquid chromatograph (HPLC),\n- device for the measurement of biomolecular interactions enabling real-time, label-free analysis of kinetics and affinity,\n- device for protein concentration measurement,\n-  immunoenzymatic assay plate reader,\n device for the analysis of protein fluorescence as a function of temperature (35\u201395\u00b0C) for the assessment of protein quality and stability at wavelengths of 330 and 350 nm,\n- semi-automated chromatographic system for antibody purification with the capability of protein concentration measurement (Fast Protein Liquid Chromatography (FPLC) system or equivalent).","type":{"id":3,"name":"Potencja\u0142 techniczny"},"created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 23:28:49","modified_by":null,"group_uuid":"c8681660-6bee-462c-a0e2-b9c389c9668e"},{"id":1800543,"description":"Wykonawca posiada w swoim zespole co najmniej 4 osoby uprawnione do pracy w laboratorium, posiadaj\u0105ce:\n- wykszta\u0142cenie wy\u017csze (minimum stopie\u0144 licencjata) w zakresie nauk przyrodniczych, w szczeg\u00f3lno\u015bci: chemii, biochemii, bioin\u017cynierii lub dziedzin pokrewnych,\n- co najmniej 2-letnie do\u015bwiadczenie zawodowe w obszarze pokrewnym, takim jak technologia przeciwcia\u0142, biologia molekularna lub biochemia,\n- do\u015bwiadczenie w pracy z przeciwcia\u0142ami lub fragmentami przeciwcia\u0142.\n***\nThe Tenderer has in its team at least 4 persons authorised to work in a laboratory, who possess:\n- higher education (at least a Bachelor\u2019s degree) in the field of natural sciences, in particular chemistry, biochemistry, bioengineering or related disciplines,\n- at least 2 years of professional experience in a related field, such as antibody technology, molecular biology or biochemistry,\n- experience in working with antibodies or antibody fragments.","type":{"id":4,"name":"Osoby zdolne do wykonania zam\u00f3wienia"},"created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 23:28:49","modified_by":null,"group_uuid":"97121f28-bfa4-4417-9488-01b87aefa2fa"},{"id":1800544,"description":"Sytuacja ekonomiczna i finansowa nie mo\u017ce uniemo\u017cliwia\u0107 Wykonawcy realizacji zam\u00f3wienia w okre\u015blonym w og\u0142oszeniu terminie.\n***\nThe Tenderer\u2019s economic and financial situation must not prevent the proper performance of the contract within the timeframe specified in the announcement.","type":{"id":5,"name":"Sytuacja ekonomiczna i finansowa"},"created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 23:28:49","modified_by":null,"group_uuid":"bbbef3e2-8ba3-4793-b7c1-8bce1c08a092"}],"category":{"id":1,"name":"Us\u0142uga"},"subcategory":{"id":8,"name":"Us\u0142ugi inne"},"created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 23:28:51","modified_by":null,"group_uuid":"caf0fe0e-08e7-4873-8284-d01a171b9919"}],"evaluation_criteria":[{"id":1011412,"price_criterion":false,"description":"Liczba moleku\u0142 mo\u017cliwych do wykonania w cenie wskazanej w zam\u00f3wieniu\nmax 95 pkt\n***\nNumber of molecules that can be performed within the price indicated in the order\nmax 95 points","created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 23:28:49","modified_by":null,"group_uuid":"375238cb-5000-44b1-b020-84c7ea7db21c"},{"id":1011413,"price_criterion":false,"description":"Przedmiot zam\u00f3wienia wykonany w oparciu o system zarz\u0105dzania \u015brodowiskowego ISO 14001, EMAS lub LEED (tak - 5 pkt, nie - 0 pkt)\nThe subject of the contract performed in accordance with the ISO 14001 environmental management system or EMAS or LEED (yes - 5 points, no - 0 points)","created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 23:28:49","modified_by":null,"group_uuid":"06f75dbb-6571-4a00-a6b2-ddce34b25225"}],"is_variant":false,"title":"Synteza gen\u00f3w i klonowania do wybr. wektor\u00f3w ekspresyjnych","order_node":{"id":426397},"created_by":null,"created_at":"2026-02-10 23:28:49","modified_at":"2026-02-10 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