{"status":"OK","data":{"advertisement":{"id":228853,"title":"Post\u0119powanie nr PB003/35/2023.\nUs\u0142uga polegaj\u0105ca na przeprowadzeniu bada\u0144 tolerancji, aktywno\u015bci oraz bezpiecze\u0144stwa cz\u0105steczki PB003 z wykorzystaniem humanizowanych modeli myszy.\nA service to conduct tolerability, efficacy and safety study on humanized mice model using lead molecule PB003.","partial_offer_allowed":false,"publication_date":"2023-09-25","submission_deadline":"2023-10-25 23:59:59","planned_sign_date":"2023-10-01","supplementary_orders":"-","terms_of_contract_change":null,"created_at":"2023-09-25 16:22:56","modified_at":"2023-10-26 00:00:03","contact_persons":[{"id":3163,"forename":"Karolina","surname":"Miernik","phone_number":"","email":"k.miernik@purebiologics.com","created_by":null,"created_at":"2023-12-05 14:42:15","modified_at":"2023-12-05 14:42:15","modified_by":null}],"orders":[{"id":373995,"estimated_value":null,"order_items":[{"id":422559,"description":"\nNr PB003/35/2023\nPrzedmiotem zam\u00f3wienia jest przeprowadzenie przedklinicznej oceny tolerancji, aktywno\u015bci oraz bezpiecze\u0144stwa biologicznie aktywnego zwi\u0105zku przeciwnowotworowego PB003 z wykorzystaniem humanizowanych modeli myszy. Zakres bada\u0144 b\u0119d\u0105cym przedmiotem zam\u00f3wienia jest szczeg\u00f3\u0142owo opisany w Za\u0142\u0105czniku nr 2. Przedmiot zam\u00f3wienia obejmuje r\u00f3wnie\u017c przygotowanie i dostarczenie Zamawiaj\u0105cemu raport\u00f3w z tych bada\u0144.\nZa\u0142\u0105cznik nr 2 zosta\u0142 sporz\u0105dzony w j\u0119zyku angielskim i za\u0142\u0105czony do niniejszego zapytania. \n\nThe subject of the service is to conduct a preclinical evaluation of the tolerability, activity and safety of the biologically active anticancer compound PB003 using humanized mouse models. The scope of the studies being the subject of the order is described in detail in Attachment No. 2. The subject of the order also includes the preparation and delivery of reports on these studies to the Ordering Party. Attachment No. 2 has been prepared in English and is attached to this request. ","warranty_period":null,"cpv_items":[{"id":8513,"code":"73100000-3","name":"Us\u0142ugi badawcze i eksperymentalno-rozwojowe"}],"timetable_items":[],"fulfillment_places":[{"country":"Polska","voivodeship":"dolno\u015bl\u0105skie","poviat":"Wroc\u0142aw","commune":"Wroc\u0142aw-Fabryczna","locality":"Wroc\u0142aw","created_by":null,"created_at":"2023-09-25 16:22:56","modified_at":"2023-09-25 16:22:57","modified_by":null,"id":474340,"type":{"id":1,"name":"adres"},"group_uuid":"f304a944-7d5a-4a02-ad7b-31403e858952"}],"participation_conditions":[{"id":1153575,"description":"1.\tZamawiaj\u0105cy zastrzega, \u017ce oferty mog\u0105 z\u0142o\u017cy\u0107 wy\u0142\u0105cznie Oferenci, kt\u00f3rzy:\na.\tposiadaj\u0105 niezb\u0119dn\u0105 wiedz\u0119 i do\u015bwiadczenie, w tym udokumentowane do\u015bwiadczenie\nw prowadzeniu bada\u0144 z zakresu onkologii w myszach o genotypie hNCG-hIL15 \u2013 przynajmniej 40 bada\u0144 przeprowadzonych w ci\u0105gu ostatnich 24 miesi\u0119cy;\nb.\toferuj\u0105 do bada\u0144 myszy o genotypie hNCG-hIL15, potwierdzone odpowiednimi certyfikatami;\nc.\toferuj\u0105 do projektu dedykowanego g\u0142\u00f3wnego badacza, kt\u00f3ry ma minimum 5 lat do\u015bwiadczenia w\nprowadzeniu bada\u0144 z zakresu farmakologii in vivo w dziedzinie immunoonkologii;\nd.\tposiadaj\u0105 akredytacj\u0119 AAALAC do przeprowadzania test\u00f3w na zwierz\u0119tach w ramach bada\u0144\nfarmakologicznych substancji czynnych oraz do\u015bwiadczenie w przeprowadzaniu bada\u0144 bezpiecze\u0144stwa zgodnie ze wewn\u0119trzym systemem SOP\ne.\tdysponuj\u0105 potencja\u0142em technicznym pozwalaj\u0105cym na wykonanie zam\u00f3wienia, w tym: o\u015brodek\nzwierz\u0119tarni o potwierdzonym standardzie SPF, mo\u017cliwo\u015b\u0107 przeprowadzenia bada\u0144 na co najmniej 150\nmyszach jednocze\u015bnie\nf.\tdysponuj\u0105 personelem o kwalifikacjach pozwalaj\u0105cych na wykonanie zam\u00f3wienia, w tym personelem\nposiadaj\u0105cym uprawnienia do pracy ze zwierz\u0119tami, w tym eutanazji zwierz\u0105t oraz z udokumentowanymdo\u015bwiadczeniem w pracy z humanizowanymi myszami CD34+ o genotypie hNCG-hIL15;\ng.\tposiadaj\u0105 lini\u0119 kom\u00f3rkow\u0105 HT-29 oraz udokumentowane osi\u0105gni\u0119cia z wykorzystaniem linii HT-29 do\npodsk\u00f3rnej inokulacji myszy huHSC-NCG-hIL15 w celu wszczepienia nowotworu.\n\nThe Ordering Party reserves that tender may only be submitted by the Bidders who:\na.\thave the necessary knowledge and experience, including documented experience\nin oncology studies in mice of the hNCG-hIL15 genotypes - at least 40 studies conducted in the last 24\nmonths;\nb.\tdedicate mice with hNCG-hIL15 genotypes for research, confirmed by appropriate certificates;\nc.\tdedicate a principal investigator to the project who has at least 5 years of experience in conducting\nresearch in the field of in vivo pharmacology in the field of immuno-oncology;\nd.\tare accredited by AAALAC to conduct animal testing as part of the pharmacology of active substances and experience in conducting safety studies in accordance with internal SOPs (i.e. non-GLP standards).\ne.\thave the technical potential to perform the contract, including: an animal facility with a confirmed SPF\nstandard, the ability to conduct tests on at least 150 mice simultaneously;\nf.\thave personnel qualified to perform the contract, including personnel authorized to work with animals, including euthanasia of animals, and with documented experience in working with CD34+ humanized mice with hNCG-hIL15 genotype;\ng.\thave the HT-29 and L428 cell lines and have a documented track-record of HT-29 in subcutaneous inoculation of\nhuHSC-NCG-hIL15 mice for tumor implantation.","type":{"id":4,"name":"Osoby zdolne do wykonania zam\u00f3wienia"},"created_by":null,"created_at":"2023-09-25 16:22:56","modified_at":"2023-09-25 16:22:57","modified_by":null,"group_uuid":"5a6085d0-3842-449a-b23f-57a67f78f3d9"},{"id":1153576,"description":"Oferta powinna zawiera\u0107 co najmniej:\n1.\tOferta musi by\u0107 z\u0142o\u017cona przez osob\u0119/osoby upowa\u017cnione.\n2.\tOferta powinna zawiera\u0107 podpisane przez osoby upowa\u017cnione za\u0142\u0105czniki, przynajmniej:\na). dokument upowa\u017cniaj\u0105cy/upowa\u017cnienie dla osoby sk\u0142adaj\u0105cej ofert\u0119,\nb). za\u0142\u0105cznik nr 1 - uzupe\u0142niony formularz oferty wraz z o\u015bwiadczeniami dotycz\u0105cymi Oferenta, \nc). za\u0142\u0105cznik nr 3  - o\u015bwiadczenie o braku powi\u0105za\u0144 pomi\u0119dzy podmiotami wsp\u00f3\u0142pracuj\u0105cymi.\n3.\t    Dopuszczalne jest podpisanie i z\u0142o\u017cenie oferty w formie elektronicznej.\n\n\n1.\tThe offer have to be submitted by an authorized person/persons.\n2.\tThe offer should contain attachments signed by authorized persons, at least:\na)  a document authorizing/authorization for the person submitting the offer,\na)  Attachment No. 1 \u2013 completed tender form together with statements concerning the Bidder,\nb)  Attachment No. 3 - statement on the lack of relations between cooperating entities.\n3.\tIt is acceptable to sign and submit the offer electronically.","type":{"id":6,"name":"Lista wymaganych dokument\u00f3w/o\u015bwiadcze\u0144"},"created_by":null,"created_at":"2023-09-25 16:22:56","modified_at":"2023-09-25 16:22:57","modified_by":null,"group_uuid":"141383bd-6e5f-4b51-8949-a1d9346b6232"}],"category":{"id":1,"name":"Us\u0142uga"},"subcategory":{"id":8,"name":"Us\u0142ugi inne"},"created_by":null,"created_at":"2023-09-25 16:22:56","modified_at":"2023-09-25 16:22:57","modified_by":null,"group_uuid":"f4df2a61-7071-4c54-bbd5-87ad786339c4"}],"evaluation_criteria":[{"id":643497,"price_criterion":true,"description":"Cena/ Price- 100%","created_by":null,"created_at":"2023-09-25 16:22:56","modified_at":"2023-09-25 16:22:57","modified_by":null,"group_uuid":"d00505e5-d2cd-4753-98d5-b5b5035df4d1"}],"is_variant":false,"title":"Us\u0142uga/ Service","order_node":{"id":284106},"created_by":null,"created_at":"2023-09-25 16:22:56","modified_at":"2023-09-25 16:22:57","modified_by":null}],"created_by":{"id":95,"contact_persons":[]},"modified_by":{"modified_by":null,"id":1,"contact_persons":[]},"status":{"id":2,"label":"PUBLISHED","name":"Opublikowane"},"advertiser_address_details":{"name":"Pure Biologics S.A.","identification_number_type":"nip","identification_number":"8943003192","address":{"country":"Polska","voivodeship":"dolno\u015bl\u0105skie","poviat":"Wroc\u0142aw","commune":"Wroc\u0142aw-Fabryczna","locality":"Wroc\u0142aw","created_by":null,"created_at":null,"modified_at":null,"modified_by":null,"id":601821,"street":"Du\u0144ska","number_description":"11","postcode":"54-427"},"created_by":{"id":95,"contact_persons":[]},"created_at":"2023-09-25 16:22:55","modified_at":"2023-09-25 16:22:55","modified_by":{"id":95,"contact_persons":[]},"id":229371},"advertisement":{"id":174323,"number":"2023-95-174323","publication_date":"2023-09-25","created_by":{"id":95,"contact_persons":[]},"created_at":"2023-09-25 16:22:55","modified_at":"2023-10-26 00:00:03","modified_by":{"modified_by":null,"id":1,"contact_persons":[]},"status":{"id":6,"label":"RESOLVED","name":"Rozstrzygni\u0119te"},"all_available_version_ids":[228853],"enrollment":null,"projects":[{"id":35947,"name":"\u201eUs\u0142uga produkcji i oczyszczania rekombinowanych ludzkich przeciwcia\u0142 monospecyficznych oraz bispecyficznych.\u201d","number":"0086/18","activity":{"created_by":{"modified_by":null,"id":1,"contact_persons":[]},"created_at":"2020-08-17 19:00:00","modified_at":"2020-08-17 19:00:00","modified_by":{"modified_by":null,"id":1,"contact_persons":[]}},"region":{"created_by":{"modified_by":null,"id":1,"contact_persons":[]},"created_at":"2022-02-10 21:45:42","modified_at":"2022-02-10 21:45:42","modified_by":{"modified_by":null,"id":1,"contact_persons":[]}},"institution":null,"full_number":"POIR.01.02.00-02-0086/18","perspective":{},"programme":{"created_by":{"modified_by":null,"id":1,"contact_persons":[]},"created_at":"2020-08-17 19:00:00","modified_at":"2020-08-17 19:00:00","modified_by":{"modified_by":null,"id":1,"contact_persons":[]}},"priority":{"created_by":{"modified_by":null,"id":1,"contact_persons":[]},"created_at":"2020-08-17 19:00:00","modified_at":"2020-08-17 19:00:00","modified_by":{"modified_by":null,"id":1,"contact_persons":[]}},"type":"project","created_by":{"id":95,"contact_persons":[]},"created_at":"2023-03-02 16:52:20","modified_at":"2023-03-02 16:52:20","modified_by":{"id":95,"contact_persons":[]}}],"is_author":false,"is_admin":false},"attachments":[{"origin":{"id":228853,"publication_date":"2023-09-25"},"id":1141035,"name":"Request for tender no PB003/35/2023 with Attachments","file":{"id":1271574,"name":"Request for tender no  PB003_35_2023 with Attachments .pdf","created_at":"2023-09-25 16:16:28","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1271574"},"group_uuid":"5c7a3326-c6f8-4fd3-844a-c21f13438406"},{"origin":{"id":228853,"publication_date":"2023-09-25"},"id":1141036,"name":"Attachments no. 1 and 3 for Request for tender no. PB003/35/2023- editable.","file":{"id":1271575,"name":"Attachments no. 1 and 3 for Request for tender no. PB003_35_2023- editable.docx","created_at":"2023-09-25 16:16:45","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1271575"},"group_uuid":"2005c51b-d371-436d-805b-66eff6bcdd9c"},{"origin":{"id":228853,"publication_date":"2023-09-25"},"id":1141037,"name":"PB003/35/2023_ Attachment no. 2","file":{"id":1271576,"name":"PB003_35_2023_ Attachment no. 2 .pdf","created_at":"2023-09-25 16:17:03","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1271576"},"group_uuid":"d8b5cb9d-6a47-46f9-803e-d32a704988e7"},{"origin":{"id":228853,"publication_date":"2023-09-25"},"id":1141038,"name":"Zapytanie Ofertowe nr PB003/35/2023 wraz z za\u0142\u0105cznikami.","file":{"id":1271584,"name":"Zapytanie Ofertowe nr PB003_35_2023 wraz z za\u0142\u0105cznikami.pdf","created_at":"2023-09-25 16:20:40","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1271584"},"group_uuid":"cc2ad52a-9eb3-475c-960a-ca175fcb9f2e"},{"origin":{"id":228853,"publication_date":"2023-09-25"},"id":1141039,"name":"Za\u0142\u0105czniki nr 1 i nr 3 do Zapytania Ofertowego no. PB003/35/2023","file":{"id":1271587,"name":"Za\u0142\u0105czniki nr 1 i nr 3 do Zapytania Ofertowego no. PB003_35_2023- wersja do edycji.docx","created_at":"2023-09-25 16:20:59","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1271587"},"group_uuid":"0003a90a-0a3b-443a-8e2e-d1794e6bc8dc"}]},"dictionaries":{"announcement_status_draft":1,"announcement_status_published":2},"favorite":null,"badge":null,"offer_set_badge_count":null,"question_badge_count":null}}