{"status":"OK","data":{"advertisement":{"id":205683,"title":"PB003/34/2023: \u201eUs\u0142uga polegaj\u0105ca na przeprowadzeniu bada\u0144 bezpiecze\u0144stwam, tolerancji oraz aktywno\u015bci na modelu zwierz\u0119cym dla cz\u0105steczki wiod\u0105cej PB003.\u201d\nPB003/34/2023: \u201cService to conduct safety, tolerability and potency studies on an animal model for lead molecule PB003.\u201d","partial_offer_allowed":false,"publication_date":"2023-04-28","submission_deadline":"2023-05-29 23:59:59","planned_sign_date":"2023-06-01","supplementary_orders":null,"terms_of_contract_change":null,"created_at":"2023-04-28 14:22:46","modified_at":"2023-05-30 00:00:03","contact_persons":[{"id":3163,"forename":"Karolina","surname":"Miernik","phone_number":"","email":"k.miernik@purebiologics.com","created_by":null,"created_at":"2023-12-05 14:42:15","modified_at":"2023-12-05 14:42:15","modified_by":null}],"orders":[{"id":339790,"estimated_value":null,"order_items":[{"id":385071,"description":"PB003/34/2023.\n1.\tPrzedmiotem zam\u00f3wienia s\u0105 badanie bezpiecze\u0144stwa biologicznie czynnych zwi\u0105zk\u00f3w przeciwnowotworowych z zastosowaniem terapii systemowej na humanizowanych myszach CD34+ NCG-hIL15 z ludzkimi kom\u00f3rkami nowotworowymi, szczeg\u00f3\u0142owo opisane w Za\u0142\u0105czniku nr 2. Przedmiotem zam\u00f3wienia obejmuje r\u00f3wnie\u017c przygotowanie i dostarczenie Zamawiaj\u0105cemu raport\u00f3w z tych bada\u0144.\nZa\u0142\u0105cznik nr 2 zosta\u0142 sporz\u0105dzony w jezyku angielskim i za\u0142\u0105czony do niniejszego zapytania.\n2.\tMaksymalny termin wykonania us\u0142ugi nie mo\u017ce przekroczy\u0107 15 tygodni od daty zam\u00f3wienia.\nPB003/34/2023.\n1.\tThe subject of the contract is safety study of biologically active anticancer compound using systematic treatments on CD34+humanized NCG-hIL15 mice with human tumor cells, as detailed in Attachment 2. The subject of the order also includes the preparation and delivery to the Ordering Party of reports on this study.\n2.\tThe maximum deadline for the performance of the service cannot exceed 15 weeks from the date of order. \n\n","warranty_period":null,"cpv_items":[{"id":8513,"code":"73100000-3","name":"Us\u0142ugi badawcze i eksperymentalno-rozwojowe"}],"timetable_items":[],"fulfillment_places":[{"country":"Polska","voivodeship":"dolno\u015bl\u0105skie","poviat":"Wroc\u0142aw","commune":"Wroc\u0142aw-Fabryczna","locality":"Wroc\u0142aw","created_by":null,"created_at":"2023-04-28 14:22:46","modified_at":"2023-04-28 14:22:52","modified_by":null,"id":433717,"type":{"id":1,"name":"adres"},"group_uuid":"84d23c33-72ea-455d-aafb-65ed70673abe"}],"participation_conditions":[{"id":1050902,"description":"1.\tZamawiaj\u0105cy zastrzega, \u017ce oferty mog\u0105 z\u0142o\u017cy\u0107 wy\u0142\u0105cznie Oferenci, kt\u00f3rzy:\na)\tposiadaj\u0105 niezb\u0119dn\u0105 wiedz\u0119 i do\u015bwiadczenie, w tym udokumentowane do\u015bwiadczenie \nw prowadzeniu bada\u0144 z zakresu onkologii w myszach o genotypie hNCG-hIL15 \u2013 przynajmniej 40 bada\u0144 przeprowadzonych w ci\u0105gu ostatnich 24 miesi\u0119cy; \nb)\toferuj\u0105do bada\u0144 myszy o genotypie hNCG-hIL15, potwierdzone odpowiednimi certyfikatami;\nc)\toferuj\u0105 do projektu dedykowanego g\u0142\u00f3wnego badacza, kt\u00f3ry ma minimum 5 lat do\u015bwiadczenia w prowadzeniu bada\u0144 z zakresu farmakologii in vivo w dziedzinie immunoonkologii;\nd)\tposiadaj\u0105 akredytacj\u0119 AAALAC do przeprowadzania test\u00f3w na zwierz\u0119tach w ramach bada\u0144 farmakologicznych substancji czynnych oraz do\u015bwiadczenie w przeprowadzaniu bada\u0144 zgodnie ze standardowymi procedurami post\u0119powania (SOP). \ne)\tdysponuj\u0105 potencja\u0142em technicznym pozwalaj\u0105cym na wykonanie zam\u00f3wienia, w tym: o\u015brodek zwierz\u0119tarni o potwierdzonym standardzie SPF, mo\u017cliwo\u015b\u0107 przeprowadzenia bada\u0144 na co najmniej 86 myszach jednocze\u015bnie; \nf)\tdysponuj\u0105 personelem o kwalifikacjach pozwalaj\u0105cych na wykonanie zam\u00f3wienia, w tym personelem posiadaj\u0105cym uprawnienia do pracy ze zwierz\u0119tami, w tym eutanazji zwierz\u0105t oraz z udokumentowanym do\u015bwiadczeniem w pracy z humanizowanymi myszami CD34+ o genotypie hNCG-hIL15;\ng)\tposiadaj\u0105 lini\u0119 kom\u00f3rkow\u0105 HT-29 oraz udokumentowane osi\u0105gni\u0119cia z wykorzystaniem linii HT-29 do podsk\u00f3rnej inokulacji myszy huHSC-NCG-hIL15 w celu wszczepienia nowotworu.\n\n1.\tThe Ordering Party reserves that tender may only be submitted by the Bidders who:\na)\thave the necessary knowledge and experience, including documented experience \nin oncology studies in mice of the hNCG-hIL15 genotypes - at least 40 studies conducted in the last 24 months;\nb)\tdedicate mice with hNCG-hIL15 genotypes for research, confirmed by appropriate certificates;\nc)\tdedicate a principal investigator to the project who has at least 5 years of experience in conducting research in the field of in vivo pharmacology in the field of immuno-oncology;\nd)\tare accredited by AAALAC to conduct animal testing as part of the pharmacology of active substances. and experience in conducting animal studies in accordance with internal SOPs (i.e. non-GLP standards).\ne)\thave the technical potential to perform the contract, including: an animal facility with a confirmed SPF standard, the ability to conduct tests on at least 86 mice simultaneously;\nf)\thave personnel qualified to perform the contract, including personnel authorized to work with animals, including euthanasia of animals, and with documented experience in working with CD34+ humanized mice with hNCG-hIL15 genotype.\ng)\thave the HT-29 cell line and have a documented track-record of HT-29 in subcutaneous inoculation of huHSC-NCG-hIL15 mice for tumor implantation","type":{"id":4,"name":"Osoby zdolne do wykonania zam\u00f3wienia"},"created_by":null,"created_at":"2023-04-28 14:22:46","modified_at":"2023-04-28 14:22:52","modified_by":null,"group_uuid":"bfc9a00c-33f2-4ac7-8e1e-1d18df486911"}],"category":{"id":1,"name":"Us\u0142uga"},"subcategory":{"id":8,"name":"Us\u0142ugi inne"},"created_by":null,"created_at":"2023-04-28 14:22:46","modified_at":"2023-04-28 14:22:52","modified_by":null,"group_uuid":"f20341be-328f-4344-8d62-bccbe9763f15"}],"evaluation_criteria":[{"id":589398,"price_criterion":true,"description":"Cena 100%\nPrice 100%","created_by":null,"created_at":"2023-04-28 14:22:46","modified_at":"2023-04-28 14:22:52","modified_by":null,"group_uuid":"4b706563-1edf-447c-929a-d550d6e6ae47"}],"is_variant":false,"title":"Us\u0142uga in vivo/ Service in vivo","order_node":{"id":258455},"created_by":null,"created_at":"2023-04-28 14:22:46","modified_at":"2023-04-28 14:22:52","modified_by":null}],"created_by":{"id":95,"contact_persons":[]},"modified_by":{"modified_by":null,"id":1,"contact_persons":[]},"status":{"id":2,"label":"PUBLISHED","name":"Opublikowane"},"advertiser_address_details":{"name":"Pure Biologics S.A.","identification_number_type":"nip","identification_number":"8943003192","address":{"country":"Polska","voivodeship":"dolno\u015bl\u0105skie","poviat":"Wroc\u0142aw","commune":"Wroc\u0142aw-Fabryczna","locality":"Wroc\u0142aw","created_by":null,"created_at":null,"modified_at":null,"modified_by":null,"id":536049,"street":"Du\u0144ska","number_description":"11","postcode":"54-427"},"created_by":{"id":95,"contact_persons":[]},"created_at":"2023-04-28 14:22:46","modified_at":"2023-04-28 14:22:46","modified_by":{"id":95,"contact_persons":[]},"id":206159},"advertisement":{"id":156958,"number":"2023-95-156958","publication_date":"2023-04-28","created_by":{"id":95,"contact_persons":[]},"created_at":"2023-04-28 14:22:46","modified_at":"2023-05-30 00:00:03","modified_by":{"modified_by":null,"id":1,"contact_persons":[]},"status":{"id":6,"label":"RESOLVED","name":"Rozstrzygni\u0119te"},"all_available_version_ids":[205683],"enrollment":null,"projects":[{"id":35947,"name":"\u201eUs\u0142uga produkcji i oczyszczania rekombinowanych ludzkich przeciwcia\u0142 monospecyficznych oraz bispecyficznych.\u201d","number":"0086/18","activity":{"created_by":{"modified_by":null,"id":1,"contact_persons":[]},"created_at":"2020-08-17 19:00:00","modified_at":"2020-08-17 19:00:00","modified_by":{"modified_by":null,"id":1,"contact_persons":[]}},"region":{"created_by":{"modified_by":null,"id":1,"contact_persons":[]},"created_at":"2022-02-10 21:45:42","modified_at":"2022-02-10 21:45:42","modified_by":{"modified_by":null,"id":1,"contact_persons":[]}},"institution":null,"full_number":"POIR.01.02.00-02-0086/18","perspective":{},"programme":{"created_by":{"modified_by":null,"id":1,"contact_persons":[]},"created_at":"2020-08-17 19:00:00","modified_at":"2020-08-17 19:00:00","modified_by":{"modified_by":null,"id":1,"contact_persons":[]}},"priority":{"created_by":{"modified_by":null,"id":1,"contact_persons":[]},"created_at":"2020-08-17 19:00:00","modified_at":"2020-08-17 19:00:00","modified_by":{"modified_by":null,"id":1,"contact_persons":[]}},"type":"project","created_by":{"id":95,"contact_persons":[]},"created_at":"2023-03-02 16:52:20","modified_at":"2023-03-02 16:52:20","modified_by":{"id":95,"contact_persons":[]}}],"is_author":false,"is_admin":false},"attachments":[{"origin":{"id":205683,"publication_date":"2023-04-28"},"id":992362,"name":"Zapytanie Ofertowe nr PB003/34/2023 wraz z Za\u0142. 1, Za\u0142.3","file":{"id":1105919,"name":"Zapytanie Ofertowe nr PB003_34_2023 wraz z Za\u0142. 1, Za\u0142.3.pdf","created_at":"2023-04-28 14:18:46","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1105919"},"group_uuid":"7e0aa2e1-255a-4b74-99d0-338d42a9709b"},{"origin":{"id":205683,"publication_date":"2023-04-28"},"id":992363,"name":"Request for tender no PB003/34/2023 with Att. 1, Att. 3","file":{"id":1105923,"name":"Request for tender no PB003_34_2023 with Att. 1, Att. 3.pdf","created_at":"2023-04-28 14:19:05","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1105923"},"group_uuid":"9c891111-5467-44f0-ab19-459293486b12"},{"origin":{"id":205683,"publication_date":"2023-04-28"},"id":992364,"name":"Za\u0142\u0105czniki nr 1 i 3 do post\u0119powania nr PB003/34/2023","file":{"id":1105925,"name":"Za\u0142\u0105czniki nr 1 i 3 do post\u0119powania nr PB003_34_2023.docx","created_at":"2023-04-28 14:19:27","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1105925"},"group_uuid":"d518c2f1-cdce-4a9f-8d88-af7624338ab9"},{"origin":{"id":205683,"publication_date":"2023-04-28"},"id":992365,"name":"Attachments no. 1 and 3 for Request for tender PB003/34/2023","file":{"id":1105927,"name":"Attachments no. 1 and 3 for Request for tender PB003_34_2023.docx","created_at":"2023-04-28 14:19:44","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1105927"},"group_uuid":"e0b496d5-065a-44b8-9fb4-7a90186322b9"},{"origin":{"id":205683,"publication_date":"2023-04-28"},"id":992366,"name":"Za\u0142\u0105cznik nr 2_ Attachment no 2","file":{"id":1105928,"name":"Za\u0142\u0105cznik nr 2_ Attachment no 2.pdf","created_at":"2023-04-28 14:20:05","created_by":{"forename":"Karolina","surname":"Miernik"},"uri":"/api/files/1105928"},"group_uuid":"4a240f50-034f-41c4-afc4-69a92892f764"}]},"dictionaries":{"announcement_status_draft":1,"announcement_status_published":2},"favorite":null,"badge":null,"offer_set_badge_count":null,"question_badge_count":null}}